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In vitro pharmacological parameters for ATV and RDV against SARS-CoV-2 variants in Calu-3 cells.
| ATV | RDV | ||||||
|---|---|---|---|---|---|---|---|
| Strain | MOI | EC50 (μM) | CC50 (μM) | SI | EC50 (μM) | CC50 (μM) | SI |
| B.1 | 0.1 | 0.490 ± 0.020 | 312 ± 8 | 637 | 0.461 ± 0.038 | 512 ± 30 | 1111 |
| B.1 | 0.001 | 0.321 ± 0.016 | 972 | 0.225 ± 0.019 | 2276 | ||
| P1 (formally B.1.1.28) | 0.1 | 0.399 ± 0.020 | 782 | 0.113 ± 0.010 | 4530 | ||
