Figure 4.

Turn angle is dose dependently increased by buspirone. Turn angle as a function of time (1-min intervals) is shown for ABSK (A) and WT (B) zebrafish. The legends show the buspirone concentrations employed (blue line with rectangle 0 mg/L, green line with circle 5 mg/L, yellow line with triangle 20 mg/L, and purple line with upside down triangle 80 mg/L). (C) shows the average turn angle calculated for the entire 30 min recording session, pooled for the two populations, exhibited by the zebrafish exposed to the different concentrations of buspirone (indicated underneath the X axis and also by the same color coding as in (A,B)). Means + S.E.M. are shown. The results of Tukey HSD test are shown as letters above each bar of the bar graph (C). Bars that do not share one letter in common represent buspirone treatment groups that are significantly (p < 0.05) different from each other. For detailed results of statistical analyses, see Results.