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. 2022 Jan 13;23(2):830. doi: 10.3390/ijms23020830

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A heatmap representing the result of clustering of cancer-specific CGI methylation in gastric cancer based on TCGA Illumina 450K array data. Note the existence of two different clusters with high levels of GI methylation: MSI-associated (MSI-CIMP) and EBV-associated (EBV-CIMP). The heatmap was generated based on unsupervised clustering (COMMUNAL R package) of CpG probes located in the proximity (±500 bp) of transcription start sites (TSS) that displayed high cancer-specific methylation [79]. The extraction of CGI methylation, together with CIMP assignments, were described previously in our work [80].