Table 3.
Antibacterial effect expressed by the minimal inhibitory concentration (MIC) of short peptides derived from snake β-defensins on bacteria.
| MIC (µM) | |||||
|---|---|---|---|---|---|
| Peptides | E. coli | S. aureus | M. luteus | K. pneumoniae | C. freundii |
| PS1 | 56.5 | 56.5 | 28.4 | >452 | 113 |
| PS2 | 415 | 415 | 26.1 | >415 | >415 |
| PS3 | >500 | 125 | 31.5 | >500 | >500 |
| PS4 | >423 | >423 | 26.6 | >423 | >423 |
| PS5 | 55.2 | 27.7 | 13.9 | 27.7 | 110 |
| PS6 | 697 | 349 | 43.8 | >697 | >697 |
The MIC was determined as the lowest concentration that results in no visible bacterial growth in microbroth dilution assay [28]. The assays were performed in three independent experiments. All the short peptides tested did not inhibit the growth of Providencia rettgeri, Serratia marcenses, and Morganella morganii.