Table 1.

Performance of the newborn and childhood methylation risk scores calculated using five different methods.

MRS Method †	Newborn MRS: 6 CpGs AUC (95% CI)	Childhood MRS: 110 CpGs AUC (95% CI)
1	0.55 (0.50–0.60) ‡	0.53 (0.48–0.59)
2	0.54 (0.48, 0.59)	0.54 (0.49, 0.59) ‡
3	0.49 (0.44, 0.55)	0.53 (0.48, 0.59)
4	0.53 (0.48, 0.59)	0.53 (0.48, 0.59)
5	0.52 (0.47, 0.58)	0.53 (0.48, 0.59)

^† Full descriptions of the MRS methods are detailed in the supplementary material. ^‡ Scores offering the best discriminative performance, and which were used in subsequent analyses.