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. 2022 Jan 1;14(1):77. doi: 10.3390/v14010077

Figure 1.

Figure 1

Viral evolution detected in rectal swabs in SARS-CoV-2 infected AGM. (A) AGMs were challenged via an intranasal and intratracheal route with SARS-CoV-2 using a stock of the WA1/2020 isolate harboring several variants relative to the patient sample. (B) Sequencing of viral RNA isolated from rectal swabs at 3–4 weeks after challenge revealed a consistent pattern of variants in all three animals. (C) Two spike mutations detected in all animals map to the N-terminal domain (D215G) and near the furin cleavage site (H655Y) based on a spike structure (PBD 7K8Z [26]).