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Cytokines levels of splenic lymphocytes from immunized guinea pigs (A) and mice (B). The splenic lymphocytes were isolated on day 14 after the last immunization, and corresponding BGs were used as immunogens. The culture supernatants were harvested after 48 h and the cytokine concentration was measured by ELISA. #—p > 0.05; *—p < 0.05; **—p < 0.005; ***—p < 0.001. ****—p < 0.0001.
