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. 2022 Jan 10;27(2):447. doi: 10.3390/molecules27020447

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — Outline of synthetic route to PAT analog 10. Reagents and conditions: (i) H₂NNH₂^.H₂O, EtOH, 80 °C, 1 h, 71%; (ii) HBTU, ⁱPr₂NEt, DMF, 0 °C, 5 min then 25 °C, 30 min, 61–81%; (iii) 25% Et₂NH in CH₂Cl₂, 25 °C, 1 h, 78%; (iv) PhSH/Na₂CO₃, DMF, 25 °C, 12 h, 51%; (v) 50% TFA in CH₂Cl₂, PhSH, 25 °C, 1 h, 89%.