Table 7.
Anti-inflammatory marine xanthone.
| Name | Activity | Source | Ref. |
|---|---|---|---|
| Norlichexanthone (17) | COX-2 (IC50 = 34.3 µM) | Stachybotry sp. (ZSDS1F1-2) isolated from a sponge collected at Xisha Island | [34] |
| Yicathin C (18) | NO inhibition (27.0 ± 3.2%); NF-κB inhibition (56.8 ± 5.7%) | Aspergillus europaeus (WZXY-SX-4-1) isolated from Xestospongia testudinaria | [99] |
| IL-6 cytokine % at 1 µM: 78.37 ± 7.78% | Aspergillus wentii isolated from Gymnogongrus flabelliformis collected at Pingtan Island | [4] | |
| Yicathin B (19) | IL-6 cytokine % at 10 µM: 95.65 ± 17.21% | ||
| NO inhibition (35.3 ± 3.9%); NF-κB inhibition (81.2 ± 8.3%) | Aspergillus europaeus (WZXY-SX-4-1) isolated from Xestospongia testudinaria | [99] | |
| 1,3,6-trihydroxy-8-methylxanthone (45) | COX-2 (IC50 = 12.2 µM) | Arthrinium sp. (ZSDS1-F3) isolated from a sponge collected at Xisha Islands | [100] |
| Calyxanthone (46) | NO inhibition (17.6 ± 5.1) NF-κB: 63.7 ± 5.6 |
Aspergillus europaeus (WZXY-SX-4-1) isolated from Xestospongia testudinaria | [99] |
| Yicathin A (47) | NO inhibition (23.7 ± 4.8%); NF-κB inhibition (13.0 ± 9.8%) | ||
| Euroanthone A (166) | NO inhibition (42.2 ± 2.3%); NF-κB inhibition (68.8 ± 7.0%) | ||
| Euroanthone B (167) | NO inhibition (23.4 ± 3.3%); NF-κB inhibition (52.3 ± 10.6%) |
COX: Cyclooxygenase; IC50: Half maximal inhibitory concentration; NF-κΒ: factor nuclear kappa B; NO: nitric oxide.