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. 2021 Dec 29;14(1):75. doi: 10.3390/pharmaceutics14010075

Table 7.

Results of kinetic analysis of FZ in vitro permeability data from the gel microemulsions through synthetic membrane.

Formulation Code Zero Order First Order Higuchi Korsmeyer–Peppas
K0
(μg/h)		 R2 K1
(h−1)		 R2 KH
(h−0.5)		 R2 KP
(h−n)		 n R2
MEGEL-FZ-D1616-CIN 6% 13.353 0.9713 0.4915 0.9164 32.738 0.8967 1.2203 0.9107 0.9819
MEGEL-FZ-D1616-CIN 10% 14.298 0.9642 0.5614 0.8834 31.374 0.8143 0.949 1.2653 0.9885
MEGEL-FZ-D1216-CIN 6% 12.851 0.9569 0.5981 0.8903 34.814 0.9436 1.402 0.6768 0.9827
MEGEL-FZ-D1216-CIN 10% 12.875 0.9862 0.4234 0.8797 30.364 0.8712 1.207 0.8062 0.9607
MEGEL-FZ-D1616-ORG 6% 12.268 0.8088 0.7620 0.8724 39.154 0.926 1.4765 0.8 0.9897
MEGEL-FZ-D1616-ORG 10% 11.798 0.8032 0.6461 0.9029 39.945 0.9391 1.5607 0.6608 0.9919
MEGEL-FZ-D1216-ORG 6% 9.4754 0.6128 0.4041 0.8331 35.729 0.7958 1.4356 0.8954 0.8956
MEGEL-FZ-D1216-ORG 10% 11.492 0.8287 0.4373 0.8495 33.892 0.9042 1.2938 0.9843 0.9616
MEGEL-FZ-D1616-CLV 6% 13.023 0.9834 0.3202 0.7972 29.131 0.8379 1.0285 1.0796 0.9928
MEGEL-FZ-D1616-CLV 10% 12.139 0.9864 0.2133 0.8400 25.540 0.7916 0.9058 1.096 0.939

K0: Zero-order release constant; K1: First-order release constant; KH: Higuchi release constant; KP: Korsmeyer–Peppas release constant; n: diffusion coefficient in the Korsmeyer–Peppas model; R2: determination coefficient.