Table 1.
List of mtDNA mutations associated with CAD.
| Mutation | Gene | Other Notes | References | |
|---|---|---|---|---|
| Mt5568 (A > G) | tRNATrp | Iranian CAD Patients | [34] | |
| Mt5711 (T > A) | tRNAAsn | |||
| Mt5725 (T > G) | tRNAAsn | |||
| Mt12308 (A > G) | tRNALeu (CUN) | |||
| Mt16089 (T > C) | D-loop | TG | Association with CVD risk factors in Chinese Han CAD patients | [35] |
| Mt16145 (G > A) | D-loop | TG; LVEF | ||
| Mt16089 (T > C) | D-loop | PC | ||
| Mt14178 (T > C) | MT-ND6 | TC | ||
| Mt215 (A > G) | D-loop | LDLC | ||
| Mt8231 (C > A) | MT-CO2 | Iranian CAD Patients | [36] | |
| Mt8376 (T > A) | MT-ATP8 | |||
| Mt15928 (G > A) | tRNAThr | |||
| Mt5628 (T > C) | tRNAAla | Chinese CAD patients | [37] | |
| Mt681 (T > C) | 12S rRNA | |||
| Mt5592 (A > G) | tRNAAla | |||
| mtDNA4977 Deletion | Alone or in combination with LTL associated with recurrent MACEs and all-cause mortality in Caucasian CAD patients | [38] | ||
| Associated with MACEs and all-cause mortality in Italian CAD patients | [39] | |||
| In combination with low folate level associated with high CAD risk among Chinese diabetic patients | [40] | |||
| Mt15910 (C > T) | tRNAThr | Han Chinese patients withLHON, signs of maternally inherited CHD | [41] | |