Table 4.
Associations between LVRR and the primary study endpoint (all-cause death or heart transplantation).
| Model 1 | Model 2 | Model 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p Value | HR | 95% CI | p Value | HR | 95% CI | p Value | |
| LVRR | 0.35 | 0.24–0.51 | <0.001 | 0.40 | 0.27–0.58 | <0.001 | 0.29 | 0.14–0.62 | 0.001 |
| Age (years) | – | – | – | 1.05 | 1.03–1.06 | <0.001 | 1.03 | 0.99–1.07 | 0.0765 |
| Male sex | – | – | – | 1.12 | 0.78–1.60 | 0.541 | 0.65 | 0.33–1.30 | 0.656 |
| Hypertension | – | – | – | – | – | – | 0.87 | 0.48–1.59 | 0.660 |
| Diabetes Mellitus | – | – | – | – | – | – | 1.99 | 1.09–3.64 | 0.025 |
| eGFR(mL/min) | – | – | – | – | – | – | 0.99 | 0.98–1.01 | 0.274 |
| Hemoglobin (g/L) | – | – | – | – | – | – | 1.11 | 0.92–1.33 | 0.277 |
| logNT-proBNP (ng/L) | – | – | – | – | – | – | 1.21 | 0.88–1.67 | 0.239 |
| logHF duration (months) | – | – | – | – | – | – | 1.07 | 0.89–1.27 | 0.466 |
| III-IV NYHA class | – | – | – | – | – | – | 1.95 | 1.04–3.65 | 0.037 |
| Initial iLVEDD (mm) | – | – | – | – | – | – | 0.93 | 0.87–0.99 | 0.037 |
| Initial LVEF (%) | – | – | – | – | – | – | 0.99 | 0.94–1.05 | 0.696 |
| Sinus ryhthm | – | – | – | – | – | – | 1.06 | 0.54–2.07 | 0.875 |
| Absence of LBBB | – | – | – | – | – | – | 1.24 | 0.55–2.89 | 0.602 |
| QRS complex (ms) | – | – | – | – | – | – | 1.00 | 0.99–1.01 | 0.959 |
| Aldosterone Antagonist | – | – | – | – | – | – | 1.92 | 0.88–4.16 | 0.098 |
| Diuretic | – | – | – | – | – | – | 0.63 | 0.18–2.27 | 0.486 |
| Statin | – | – | – | – | – | – | 0.68 | 0.37–1.25 | 0.226 |
| Betablocker | – | – | – | – | – | – | 0.40 | 0.16–0.99 | 0.037 |
Results presented as HRs and 95% CIs from the Cox Proportional Hazards regression models: Model 1 was unadjusted; Model 2 adjusted for age and sex; Model 3 further adjusted for the variables that were found to be associated with LVRR in the logistic regression analyses Abbreviations: CI = confidence interval; eGFR = estimated glomerular filtration rate; HF = heart failure; HR = hazard ratio; iLVEDD = indexed left ventricular end-diastolic diameter; LBBB = left bundle branch block; LVEF = left ventricle ejection fraction; LVRR = left ventricular reverse remodelling; NTproBNP = N-terminal prohormone of brain natriuretic peptide; NYHA = New York Heart Association.