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. 2021 Dec 21;14(1):5. doi: 10.3390/v14010005

Figure 3.

Figure 3

Recognition of SARS-CoV-2 infected cells correlates with recognition of 293T cells expressing Spike, pseudoviral neutralization and ADCC. Recognition of SARS-CoV-2 D614G (A–F) or Alpha (G,H) variants infected (N+) pAECs by plasma from convalescent (A–C) or vaccinated individuals (D–H) correlates with (A,D,G) binding to 293T Spike expressing cells [5,27], (B,E,H) pseudovirus neutralization [5,27], and (C,F) ADCC activity using CEM-NKr cells stably expressing SARS-CoV-2 Spike [5,27]. Panels (A–C) show results generated using plasma from convalescent donors recovered 6 (open circle) or 11 (red triangle) weeks after the onset of symptoms. Panels (D–H) show data generated using plasma from nine individuals who were SARS-CoV-2 naïve and vaccinated obtained before vaccination (V0—open circle), at 3 weeks (V1—black triangle) and 12 weeks (V2—green triangle) after the first mRNA dose, or 3 weeks after the second dose (V3—red triangle) (administered with a 16-week interval between doses). Statistical significance was tested using Pearson (A–C) or Spearman (D–H) rank correlation tests based on statistical normality (** p < 0.01, *** p < 0.001, and **** p < 0.0001).