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Transcriptomic analysis revealed 3D-induced hAMSC bioactivity. Upregulated genes involved in (a) proliferation/differentiation, (b) immunomodulatory, and (c) angiogenesis pathways were validated using qRT-PCR, indicating a similar trend. (d) Protein–protein interaction (PPI) network relied on experimentally derived functional and/or structural evidence, including the upregulated genes found.
