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. 2021 Dec 27;12(1):34. doi: 10.3390/life12010034

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Metabolite analyses results of mouse liver and feces using CE- and LC-TOFMS. (A) Simplified schematics of the kynurenine pathway. (B) Simplified schematic of the metabolic pathway related to the methionine cycle, urea cycle, and polyamine metabolism compounds. (C) Metabolic simplified schematic pathways of primary and secondary bile acids. The production process of tyramine and trimethylamine-N-oxide (D), and lipopolysaccharide (LPS) (E). Heatmap showing hierarchical clustering analysis of metabolomic results of the liver (F) and feces (G). AD mice were fed diets containing L-arginine + limonoids (ALA), limonoids alone (AL), or a normal diet alone (AC).

Metabolite analyses results of mouse liver and feces using CE- and LC-TOFMS. (A) Simplified schematics of the kynurenine pathway. (B) Simplified schematic of the metabolic pathway related to the methionine cycle, urea cycle, and polyamine metabolism compounds. (C) Metabolic simplified schematic pathways of primary and secondary bile acids. The production process of tyramine and trimethylamine-N-oxide (D), and lipopolysaccharide (LPS) (E). Heatmap showing hierarchical clustering analysis of metabolomic results of the liver (F) and feces (G). AD mice were fed diets containing L-arginine + limonoids (ALA), limonoids alone (AL), or a normal diet alone (AC).