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. 2022 Jan 9;14(1):153. doi: 10.3390/pharmaceutics14010153

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of free TQ and PEG-Lip-TQ on body weight and LD₅₀ (A) Average body weight by free TQ during the experiment period in phase 1, (B) Average body weight of surviving animals by free TQ after 14 days in phase 1, (C) Average body weight by free TQ during the experiment period in phase 2, (D) Average body weight of surviving animals by free TQ after 14 days in phase 2, (E) Average body weight by PEG-Lip-TQ during the experiment period in phase 1, (F) Average body weight of surviving animals by free PEG-Lip-TQ after 14 days in phase 1, (G) Average body weight by PEG-Lip-TQ during the experiment period in phase 2, (H) Average body weight of surviving animals by free PEG-Lip-TQ after 14 days in phase 2, (I) LD₅₀ of free TQ and PEG-Lip-TQ. The values are expressed as mean ± SE of three independent experiments. * Significant difference between the treated groups, p-value < 0.05, **** Significant difference between the treated groups, p-value < 0.0001.

Effect of free TQ and PEG-Lip-TQ on body weight and LD₅₀ (A) Average body weight by free TQ during the experiment period in phase 1, (B) Average body weight of surviving animals by free TQ after 14 days in phase 1, (C) Average body weight by free TQ during the experiment period in phase 2, (D) Average body weight of surviving animals by free TQ after 14 days in phase 2, (E) Average body weight by PEG-Lip-TQ during the experiment period in phase 1, (F) Average body weight of surviving animals by free PEG-Lip-TQ after 14 days in phase 1, (G) Average body weight by PEG-Lip-TQ during the experiment period in phase 2, (H) Average body weight of surviving animals by free PEG-Lip-TQ after 14 days in phase 2, (I) LD₅₀ of free TQ and PEG-Lip-TQ. The values are expressed as mean ± SE of three independent experiments. * Significant difference between the treated groups, p-value < 0.05, **** Significant difference between the treated groups, p-value < 0.0001.