Table 3.

Distribution of PCV3 (IHC or ISH) and microscopic lesions (H&E).

Organ	Study A	Study B	Study C
Heart	IHC: + Myocarditis Myolysis and epicardial necrosis Hemorrhage Eosinophil infiltration	ISH: + Lymphoplasmacytic myocarditis Periarteritis	ISH: + Lymphoplasmacytic myocarditis and periarteritis
Kidney	IHC: + Interstitial glomerulonephritis	ISH: + Lymphoplasmacytic interstitial nephritis Periarteritis	ISH: + Lymphoplasmacytic interstitial nephritis and periarteritis
Intestine	IHC: + Lymphocyte infiltration Epithelial degeneration/necrosis Eosinophil infiltration	ISH: − Lymphoplasmacytic periarteritis Arteritis of the serosa	ISH: + Lymphoplasmacytic periarteritis and arteritis of the serosa
Spleen	IHC: + Lymphoid depletion/necrosis Hemorrhage	Absent (ISH and H&E)	ISH: + Lymphoplasmacytic periarteritis and arteritis
Liver	IHC: + Congestion Hepatocyte atrophy	Absent (ISH and H&E)	ISH: + Lymphoplasmacytic hepatitis
Lung	IHC: + Lymphoplasmacytic and histiocytic bronchointersitial pneumonia	Absent (ISH and H&E)	Absent (ISH and H&E)
TLN	IHC: + Lymphocytic necrosis Congestion and hemorrhage Eosinophil infiltration	Absent (ISH and H&E)	Absent (ISH and H&E)
MLN	IHC: + Lymphoid depletion/necrosis Eosinophil infiltration	Absent (ISH and H&E)	Absent (ISH and H&E)
ILN	IHC: + Lymphoid depletion Hyperplasia of epithelial-like cells Eosinophil infiltration	Absent (ISH and H&E)	Absent (ISH and H&E)
Brain	N/A (IHC and H&E)	Absent (ISH and H&E)	ISH: − Lymphoplasmacytic encephalitis with perivasculitis

Study A [18]; Study B [17]; Study C [19]; Study D [13]; IHC, immunohistochemistry; ISH, in situ hybridization; H&E, hematoxylin and eosin staining (histopathology); +, present; -, absent; N/A, data not available; TLN, tracheobronchial lymph nodes; MLN, mesenteric lymph nodes; ILN, inguinal lymph nodes; Study D reported only intestinal lesions, in which, epithealial degeneration and necrosis was found.