Table 7.
Optimization parameters presented as function of independent variables analyzed using response surface methodology for microemulsions MELSA 1–MELSA 13.
| Variable | Independent Variables | Dependent Variables | |||||
|---|---|---|---|---|---|---|---|
| X1 | X2 | X3 | Y1 | Y2 | Y3 | ||
| Formulation | Tween 80/PG (%) |
Lecithin (%) |
Oil (%) |
1 Clarity | Viscosity (cP) |
Droplet Size (nm) |
Adhesion Work (mN/m) |
| MELSA 1 | 20 | 0.1 | 1.5 | ++ | 20.65 ± 2.05 | 11.35 ± 1.05 | 60.71 ± 1.96 |
| MELSA 2 | 40 | 0.1 | 1.5 | +++ | 292.69 ± 4.18 | 3.32 ± 1.85 | 67.52 ± 2.99 |
| MELSA 3 | 20 | 0.5 | 1.5 | ++ | 27.89 ± 2.63 | 21.88 ± 1.25 | 62.04 ± 0.53 |
| MELSA 4 | 40 | 0.5 | 1.5 | +++ | 188.17 ± 3.03 | 5.88 ± 1.16 | 76.91 ± 2.90 |
| MELSA 5 | 20 | 0.3 | 1 | +++ | 24.33 ± 1.15 | 3.43 ± 1.73 | 72.61 ± 3.08 |
| MELSA 6 | 40 | 0.3 | 1 | +++ | 287.77 ± 4.30 | 1.58 ± 0.20 | 81.00 ± 2.49 |
| MELSA 7 | 20 | 0.3 | 2 | + | 16.94 ± 2.16 | 37.72 ± 4.55 | 58.64 ± 1.25 |
| MELSA 8 | 40 | 0.3 | 2 | +++ | 217.73 ± 3.54 | 2.17 ± 1.54 | 62.13 ± 1.66 |
| MELSA 9 | 30 | 0.1 | 1 | +++ | 48.47 ± 3.06 | 5.14 ± 2.15 | 60.80 ± 2.38 |
| MELSA 10 | 30 | 0.5 | 1 | +++ | 34.82 ± 1.06 | 5.30 ± 2.53 | 68.14 ± 7.88 |
| MELSA 11 | 30 | 0.1 | 2 | + | 51.23 ± 3.33 | 6.45 ± 2.55 | 52.72 ± 1.44 |
| MELSA 12 | 30 | 0.5 | 2 | + | 39.29 ± 2.08 | 26.02 ± 3.78 | 59.79 ± 1.39 |
| MELSA 13 | 30 | 0.3 | 1.5 | +++ | 45.84 ± 2.67 | 4.11 ± 1.65 | 59.64 ± 1.62 |
1 Notation of clarity parameters: “+” was attributed for an opalescent system, “++”—for a low clarity system, and “+++”—for a high clarity system.