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. 2022 Jan 20;148(3):268–276. doi: 10.1001/jamaoto.2021.4052

Figure 4. Visualization of Radiologic irAEs vs SUVmax Changes in Primary OCSCC and Ipsilateral Cervical Lymph Nodes.

Figure 4.

A, Nο correlation was found between pathologic response in primary tumor and visualization of radiologic immune-related adverse effects (irAEs) on the T1 fluoro-[18F]-deoxy-2-D-glucose positron emission tomography/computed tomography (FDG-PET/CT). B, Change in maximum standardized uptake value (SUVmax) of the most FDG-avid metastatic cervical lymph nodes between T0 and T1 was not different between participants with (median 14%, range −11% to 75%) and without radiologic irAEs (median 20%, range −48% to 35%, ESwrs = −5% [90% CI, –20% to 45%] for with or without) after preoperative immunotherapy. C, Primary oral cavity squamous cell cancer (OCSCC) SUVmax increased more in participants with (median 34%, range −5 to 47%) vs without (median −1%, range −29 to 25%, ESwrs = 30% [90% CI, 6% to 67%] for with or without) radiologic irAEs on T1 FDG-PET/CTs.