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. 2022 Jan 20;8(3):e216871. doi: 10.1001/jamaoncol.2021.6871

Figure 1. Associations of Androgen Deprivation Therapy Duration With Distant Metastasis-Free Survival and Overall Survival in Men Receiving External Beam Radiotherapy With or Without Brachytherapy Boost.

Figure 1.

A and B, Forest plot comparison ADT duration of 6 to less than 18 months ADT vs less than 6 months. C and D, Comparison of ADT duration of 18 months or more vs 6 to less than 18 months; natural cubic splines evaluating nonlinear associations between ADT duration and DMFS for patients receiving EBRT or EBRT+BT. An arrow on each spline indicates the ADT duration threshold (lowest in [HR]); higher numerical values on the y-axis indicate a less favorable DMFS, and lower values, a more favorable DMFS.

Abbreviations: ADT, androgen deprivation therapy; DMFS, distant metastasis-free survival; EBRT, external beam radiotherapy; EBRT+BT, external beam radiotherapy plus brachytherapy boost; HR, hazard ratio; OS, overall survival.