Skip to main content
. 2022 Jan 20;8(3):e216871. doi: 10.1001/jamaoncol.2021.6871

Figure 2. Associations of Longer Duration of Androgen Deprivation Therapy With Distant Metastasis-Free Survival and Overall Survival.

Figure 2.

A and B, Kaplan-Meier curves for DMFS and OS for patients receiving EBRT+BT and 6 or 18 months of ADT on the RADAR trial. Because the RADAR comparison for patients receiving EBRT+BT is the direct randomization from that trial, unadjusted curves are presented. C and D, Adjusted survival curves for DMFS and OS for the cross-trial comparison between patients receiving ADT for 6 and 18 months (RADAR) vs 28 months (DART). Survival curves were adjusted using an inverse probability treatment weighting approach wherein propensity scores included the following independent variables: treatment type (if relevant), ln(iPSA), clinical T category, Gleason grade group, and age (y) at treatment.

Abbreviations: ADT, androgen deprivation therapy; DART, Deprivación Androgénica y Radio Terapía (Androgen Deprivation and Radiation Therapy) 01/05 trial; DMFS, distant metastasis-free survival; EBRT, external beam radiotherapy; EBRT+BT, external beam radiotherapy plus brachytherapy boost; OS, overall survival; RADAR, the Randomized Androgen Deprivation and Radiotherapy 03/04 trial.