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. 2022 Jan 10;70(2):577–583. doi: 10.1021/acs.jafc.1c07520

Table 1. Anti-/Pro-inflammatory Cytokines’ Ratioa.

  C LPS H2 [100μM]
IL10/IFN-γ 1.05 ± 0.14a 0.75 ± 0.15b 1.10 ± 0.19a
IL10/TNF 0.99 ± 0.07a 0.88 ± 0.05a 1.14 ± 0.11b
IL10/IL-6 1.01 ± 0.10a 0.90 ± 0.03a 0.96 ± 0.07a
  C LPS H3 [25μM]
IL10/IFN-γ 1.00 ± 0.03a 0.93 ± 0.05a 1.34 ± 0.06b
IL10/TNF 1.00 ± 0.02a 0.92 ± 0.02a 1.44 ± 0.12b
IL10/IL-6 1.00 ± 0.02a 0.90 ± 0.01a 1.32 ± 0.13b
a

Ratios between anti-inflammatory (IL-10) and pro-inflammatory (IFN-γ, TNF, and IL-6) cytokines quantified in HepG2 cells stimulated or not with LPS and treated with H2 (100 μM) or H3 (25 μM). Data are presented as mean ± SD and were analyzed by one-way ANOVA, followed by Tukey’s post-hoc test. Different letters indicate statistically significant differences (p ≤ 0.05). C, unstimulated control group; IFN-γ, interferon-γ; IL, interleukin; LPS, lipopolysaccharide-stimulated cells; TNF, tumor necrosis factor.