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. 2021 Dec 25;33(1):194–205. doi: 10.1021/acs.bioconjchem.1c00537

Figure 3.

Figure 3

In vivo pharmacokinetics of 99mTc-N49 and 111In-N48. (A) Biodistribution as determined after dissection of 99mTc-N49 (3 MBq/mouse) and 111In-N48 (10 MBq/mouse) 2, 4, and 24 h p.i. (0.3 nmol, n = 5/group). Biodistribution was determined in mice bearing subcutaneous LS174T-PSMA and LS174T wild-type xenografts. Data are expressed as %ID/g ± SD; ** indicates p < 0.01. (B) Representative μSPECT/CT scans and fluorescence images of mice with s.c. LS174T-PSMA (left) and wild-type LS174T (right) tumors after i.v. injection of 99mTc-N49 (3 MBq/mouse) and 111In-N48 (10 MBq/mouse) 2, 4, and 24 h p.i.