Table 2.
Studies that report the effect of representative epidrugs in different experimental models of alcohol administration (see main text).
| Drug Used | Experimental Model | Effect | References |
|---|---|---|---|
| DNMT inhibitors | - | - | - |
| Decitabine | Mice exposed to binge and chronic ethanol. | It reduced ethanol intake. | [211] |
| 5-azacytidine | Binge exposure of mice. | It decreased ethanol intake. | [212] |
| 5-azacytidine | Mice intermittently exposed to alcohol during adolescence. | Hypermethylation of Npy and Bdnf genes appeared reduced. Anxiety-like and alcohol drinking behavior during adulthood were reduced. |
[163] |
| RG-108 | Alcohol abstinent rats. | It decreased alcohol intake. | [213] |
| HDCA inhibitors | - | - | - |
| SAHA | Rats were chronically exposed to ethanol. | Abrogated ethanol withdrawal effects | [203] |
| SAHA | Rats were administered with a liquid diet containing ethanol. | Attenuated depression-like behavior was observed during the withdrawal period. | [169] |
| SAHA | Mice | It diminished binge-like alcohol drinking. | [212] |
| SAHA and Trichostatin A | Mice chronically exposed to ethanol | Both compounds prevented ethanol withdrawal effects. | [217] |
| Trichostatin A | Alcohol-preferring (P-rats) and non-preferring (NP-rats) |
Diminished anxiety-like behavior and alcohol intake in P-rats, compared with NP-rats | [219] |
| Sodium butyrate | Ethanol-dependent rats through alcohol self-administration. | It reduced alcohol drinking. | [220] |
| Sodium butyrate | Mice under ethanol-induced behavioral sensitization. | It inhibited ethanol-induced behavioral sensitization. | [221] |
| Entinostat | Alcohol-dependent rats. | Reduced operant alcohol administration, diminished motivation to drink, and reduced relapse during abstinence. | [220, 223] |
| miRNA antagonists | - | - | - |
| Antagomir-137 | Rats administered with ethanol during the adolescence period | The compound inhibited alcohol consumption and anxiety-like behaviors. | [133] |
| AntagomiR-411 | Female CB57BL/6J mice chronically administered with alcohol. | It diminished alcohol drinking. | [228] |
| AntagomiR-494 | Rats | It mimicked the anxiolytic effect of acute ethanol treatment. | [229] |
| Let-7f-antagomiR | Rats subjected to two cycles of ethanol administration and withdrawal | Recovered deranged mitochondrial respiration induced by ethanol treatment. | [230] |