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PCSK9 inhibitors and their mechanism of action.
| Mechanism of Action | Examples |
|---|---|
| Blocking of PCSK9/LDLR complex formation | Peptides |
| Adnectins | |
| Monoclonal antibodies | |
| (alirocumab, evolocumab, bocozicumab) | |
| Suppression of PCSK9 expression | CRISPR/Cas9 technology |
| Small molecules: | |
| berberine, oleanolic acid | |
| Antisense nucleotides | |
| siRNA | |
| Interference with PCSK9 secretion | Sortilin |
| Sec24a |
