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Brain AUC for a TfRMAb alone (A) and for a TfRMAb-IDUA fusion protein (B). Brain AUC is shown for an antibody with high affinity (KD = 0.36–3.6 nM), moderate affinity (KD = 36 nM), and low affinity (KD = 360 nM). The association rate constant (kon) is the same, 106 M−1sec−1, for all antibodies. Brain AUC was computed over 48 h after a single IV administration of either 3 or 30 mg/kg.
