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. Author manuscript; available in PMC: 2022 Jan 21.
Published in final edited form as: J Hepatol. 2020 Nov 13;74(4):919–930. doi: 10.1016/j.jhep.2020.10.035

Fig. 1. Lack of IL-17A/F in antigen-specific CD8+ T cells aggravates cholangitis in K14-OVAp animals.

Fig. 1.

Cholangitis severity in K14-OVAp recipient mice on day 5 after adoptive transfer of OT-1wt or OT-1IL17ko CD8+ T cells: (A) mHAI histological activity index of H&E-stained liver sections and (B) levels of serum transaminases ASAT and ALAT. (C) Representative immunofluorescent staining of congenic cell marker CD45.1 (red, transferred T cells), CK19 (green, cholangiocytes) and nuclei (blue) performed on cryo-sections of K14-OVAp liver after adoptive cell transfer. Data are expressed as mean ± SD; n=10–17, representing pooled data from three independent experiments. Levels of significance: *p≤0,05; **p≤0,01; ***p≤0,001; ****p≤0,0001 (ordinary one-way ANOVA).