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. 2022 Jan 7;11:786120. doi: 10.3389/fonc.2021.786120

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Copyright © 2022 Gordon, Shapiro, Sarantopoulos, Juric, Lu, Zarotiadou, Connarn, Le Bruchec, Dumitru and Harvey

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histone (A) and tubulin (B) acetylation time course (average and SEM for patients treated at indicated levels on cycle 1 day 1). Dose levels indicated are 180, 360, and 480 mg of citarinostat orally once daily. Note: measurements are made on n = 3 at 180-mg level, n = 11 at 360-mg level, and n = 6 at 480-mg level. Cycle 1 day 15 measurements have similar profiles (data not shown). ACY, ACY-241 (citarinostat); MFI, mean fluorescence intensity; PTX, paclitaxel.