Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Study overview. A schematic of our anti-SARS-CoV-2 compound screening process. The anti-SARS-CoV-2 potential of 12 compounds was first analyzed through molecular docking using DockCoV2. Next, the inhibitory effect of those compounds on TMPRSS2, 3CLpro, and PLpro was tested. The RBD attachment assay indicated the ability of the compound to block the interaction between the spike RBD and ACE2. Finally, the plaque reduction assay revealed the antiviral activity of the compounds.
