. 2022 Jan 10;27(2):425. doi: 10.3390/molecules27020425

Table 1.

IC₅₀ Values of H6M and H6AQ against HDAC1 and four cancer cell lines.

Compd	In Vitro Antiproliferative Activity (IC₅₀, μM) ^a				HDAC1 Inhibition (IC₅₀, nM) ^a
Compd	HeLa	HepG2	HCT116	H1299	HDAC1 Inhibition (IC₅₀, nM) ^a
SAHA	18.54 ± 0.32	5.95 ± 0.73	4.98 ± 0.56	7.01 ± 0.55	142 ± 18
Harmine	42.56 ± 4.15	53.8 ± 5.50	43.7 ± 3.85	ND ^b	>1000
H6M	3.59 ± 0.34	3.55 ± 0.18	3.23 ± 0.14	2.57 ± 0.22	65 ± 6
H6AQ	2.08 ± 0.30	2.58 ± 0.26	1.87 ± 0.21	1.69 ± 0.31	41 ± 5

^a Each cell was treated with tested compounds for 72 h, and their cytotoxicity were determined by the MTT assay. Mean ± SD, n = 3. ^b Not detected.