Table 1.
Effects of A. muciniphila on fecal metabolomics.
| Group | Metabolites | Change 1 | log2(FC) | −log10(p) | |
|---|---|---|---|---|---|
| mum | P1 | 2,4-quinolinediol | − | 5.0125 | 2.5454 |
| P17 | quercetin | − | 3.0601 | 1.7229 | |
| 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one | − | 2.6156 | 2.4021 | ||
| N-({(1S,4S,6S)-4-[2-(4-Acetyl-1-piperazinyl)-2-oxoethyl]-6-isopropyl-3-methyl-2-cyclohexen-1-yl}methyl)-3-fluorobenzamide | −1.2058 | 2.0271 | |||
| 5(Z),8(Z),11(Z)-eicosatrienoic acid methyl ester | − | 1.4851 | 1.3538 | ||
| 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6-diol | − | 1.4208 | 1.53 | ||
| 2,4-quinolinediol | − | 1.3326 | 1.6166 | ||
| D21 | chalconaringenin | − | 2.2558 | 4.4939 | |
| chrysin | − | 2.2671 | 3.9032 | ||
| 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one | − | 4.0824 | 3.7509 | ||
| kaempferol | − | 4.2064 | 3.6954 | ||
| apigenin | − | 1.9089 | 2.7149 | ||
| quercetin | − | 3.0535 | 2.0839 | ||
| 3-methoxy-5,7,3’,4’-tetrahydroxy-flavone | − | 1.2944 | 2.0068 | ||
| 1-(3-hydroxy-3-methylpent-4-en-1-yl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol | + | −1.6698 | 1.5552 | ||
| N-({(1S,4S,6S)-4-[2-(4-Acetyl-1-piperazinyl)-2-oxoethyl]-6-isopropyl-3-methyl-2-cyclohexen-1-yl}methyl)-3-fluorobenzamide | + | −1.4211 | 1.499 | ||
| pup | B21 | ferulic acid | − | 1.3433 | 2.3336 |
| 2-deoxyadenosine | − | 1.7339 | 2.1811 | ||
| 1,2,3-propanetricarboxylic acid | + | −3.4132 | 1.9936 | ||
| dihomo-γ-linolenic acid ethyl ester | + | −1.1179 | 1.9883 | ||
| 4-dodecylbenzenesulfonic acid | + | −1.1009 | 1.9561 | ||
| N-ethylglycine | + | −1.9219 | 1.9212 | ||
| adenine | − | 1.3701 | 1.8602 | ||
| trigonelline | − | 1.8588 | 1.7411 | ||
| apigenin | − | 1.1448 | 1.6694 | ||
| 13Z,16Z-docosadienoic Acid | + | −1.3788 | 1.5585 | ||
| D-pyroglutamic acid | + | −1.0427 | 1.4999 | ||
| L-glutamic acid | + | −1.6019 | 1.4835 | ||
| isobutyric acid | − | 1.6023 | 1.4738 | ||
| stachydrine | + | −1.4942 | 1.433 | ||
| phenylacetaldehyde | − | 1.2711 | 1.3859 | ||
| 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione | − | 1.0677 | 1.3794 | ||
| acamprosate | + | −5.1411 | 1.354 | ||
| L-carnitine | + | −1.4233 | 1.354 | ||
| (1S,19R)-8,10-dioxa-4,17-diazaheptacyclo[15.4.3.01,18 04,19 05,13 07,11 014,19]tetracosa-5(13),6,11,22-tetraen-3-one | + | −1.0226 | 1.3446 | ||
| B42 | acamprosate | − | 4.3948 | 6.7137 | |
| NP-003553 | − | 1.262 | 5.2985 | ||
| NP-015980 | + | −1.8399 | 5.1508 | ||
| L-lactic acid | − | 1.1072 | 4.1074 | ||
| methyl indole-3-acetate | − | 1.3097 | 3.0721 | ||
| tridecylic acid | − | 2.6194 | 2.7511 | ||
| ursolic acid | + | −1.0904 | 2.7069 | ||
| 1-methylxanthine | + | −1.9701 | 2.4263 | ||
| 1-benzyl-3-[(1S,4S)-4-{3,5-dimethyl-1-[4-(2-methyl-2-propanyl)phenyl]-1H-pyrazol-4-yl}-2-cyclopenten-1-yl]urea | + | −1.7189 | 2.3518 | ||
| N-ethylglycine | − | 1.0197 | 2.3183 | ||
| 3-methylxanthine | + | −1.4299 | 1.9015 | ||
| indole-3-lactic acid | + | −1.2901 | 1.8742 | ||
| 5-[({(2R,4S,5R)-5-[1-methyl-3-(2-thienyl)-1H-pyrazol-5-yl]-1-azabicyclo[2.2.2]oct-2-yl}methyl)amino]-5-oxopentanoic acid | + | −3.698 | 1.8261 | ||
| salicylic acid | + | −1.6365 | 1.7769 | ||
| biotin | + | −1.0759 | 1.7525 | ||
| 4-(methylthio)-6-phenyl-2-(3-pyridyl)pyrimidine-5-carbonitrile | + | −1.6808 | 1.6331 | ||
| taurochenodeoxycholic Acid _sodium salt_ | + | −1.1365 | 1.5416 | ||
| (4aS,5R,6S,8aS)-5-[(3E)-5-methoxy-3-methyl-5-oxopent-3-en-1-yl]-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid | + | −1.2552 | 1.5266 | ||
| 4-fluoro-N-{[(1S,4S,6S)-6-isopropyl-3-methyl-4-(2-{[2-(4-morpholinyl)ethyl]amino}-2-oxoethyl)-2-cyclohexen-1-yl]methyl}benzamide | + | −1.0308 | 1.4497 | ||
| 1,2,3-propanetricarboxylic acid | − | 1.0805 | 1.4491 | ||
| cytosine | − | 1.0388 | 1.4034 | ||
| tropine | − | 1.8667 | 1.3217 | ||
| N-desmethyltramadol | + | −1.8015 | 1.3146 | ||
1 “−”: Compared with the CON group, the abundance of this metabolite at this time point in the AKK group is lower, and “+” means higher.