Table 1.

Summary of murine non-cardiac TRPM4 KO animal models.

Properties of Animal Model	Targeting Strategy	Impact on Protein	KO Animals Showed:	Possible Link to Human Diseases	Conclusion	References
2–6 month-old C57BL/6 TRPM4 KO mice	Cre-loxP–mediated recombination	No TRPM4 protein	less response to different taste stimuli	?	TRPM4 (and TRPM5) is important in the transduction of bitter, sweet, and umami tastes	[51]
6–8 week-old, male C57BL/6J TRPM4 KO mice with post status epilepticus	not stated	not stated	less water content, cerebral edema, reduced mortality, and cognitive deficit	?	TRPM4 may represent a new target for improving outcomes after status epilepticus	[52]
24–28 g weight C57BL/6 TRPM4 KO mice with unilateral spinal cord injury	Cre-loxP–mediated recombination	No TRPM4 protein	reduction in spinal cord injury lesion volume, substantial improvement in neurological function	spinal cord injury	TRPM4 upregulates and initiates secondary hemorrhage in spinal cord injury	[53]
TRPM4 KO mice	Cre-loxP–mediated recombination	No TRPM4 protein	increased stimulated Ca2+ entry and histamine, leukotrienes and tumor necrosis factor release in mast cells	anaphylactic response	TRPM4 channels are critical regulators of Ca2+ entry into mast cells	[15]
6–10 week-old C57BL/6J TRPM4 KO mice with experimental autoimmune encephalomyelitis	Cre-loxP–mediated recombination	No TRPM4 protein	Reduced axonal and neuronal injury and disease severity	multiple sclerosis	TRPM4 contributes to inflammatory effector mechanisms	[54]
8–12 week-old 129/B6 TRPM4 KO mice	not stated	not stated	increased mortality and reduced phagocytic activity of monocytes and macrophages	sepsis	TRPM4 is protective in cecal ligation and puncture-induced sepsis model	[55]
TRPM4 KO mice	Cre-loxP–mediated recombination	No TRPM4 protein	reduced dinitrophenylated human serum or stem cell factor-induced migration	inflammation reactions	TRPM4 is involved in the migration of bone-marrow-derived mast cells	[56]