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. 2021 Dec 29;14(1):49. doi: 10.3390/v14010049

Figure 3.

Figure 3

IFNAR1 antibodies enhanced RABV production in MRC-5 cells. MRC-5 cells were infected with the PM RABV strain at an MOI of 0.05. Vero cells were infected with the aG RABV strain at an MOI of 0.001. The IFNAR1 monoclonal antibodies α/β-IFNAR1 and α-IFNAR1 were incubated with MRC-5 cells 2 h before virus infection at a concentration of 1 ng/mL. (A) Total RNA from cells was extracted at 24 hpi, and the expression of IFN-α, IFN-β, and OAS1 mRNA was detected by qRT-PCR. Viral RNA (B) and titer (C) in the culture supernatant were detected by qRT-PCR and FFU assays at 168 hpi. +: RABV infection; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns p ≥ 0.05.