Table 1.

Development of sepsis definitions and parameters to detect and define sepsis.

Sepsis-1/1991 [11]	Sepsis = SIRS as a response to infection (SIRS = systemic inflammatory response syndrome) defined by ≥2 parameter:
Parameter	>38 °C or <36 °C; heart rate > 90/min; respiratory rate > 20/min or PaCO2 < 32 mmHg; white blood cell count > 12,000/µL or <4000/µL or >10% immature forms
Sepsis-2/2001 [12]	no change in definition, but additional parameters to detect sepsis and organ dysfunction:
Parameter	significant edema/Positive fluid balance; hyperglycaemia in the absence of diabetes; C-reactive protein 2× above normal; procalcitonin 2× above normal; arterial hypotension; mixed venous saturation > 70%; arterial hypoxemia; acute oliguria, creating increase ≥ 0.5 mg/dL; coagulation abnormalities, thrombocytopenia; ileus; hyperbilirubinemia; hyperlactatemia, decreased capillary refill
Sepsis-3/2016 [13]	“Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.”
Parameter	increase in SOFA-score ≥ 2 points