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. 2022 Jan 1;14(1):100. doi: 10.3390/pharmaceutics14010100
A7R Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH peptide
ACN Acetonitrile
ADME Absorption, distribution, metabolism, and excretion
Ahx 6-aminohexanoic acid
Alloc Allyloxycarbonyl group
Ao Organic phase radioactivity
Aw Aqueous phase radioactivity
Boc
COOH
Tert-butyloxycarbonyl group
Carboxyl group
Cys Cysteine
Dab 2,4-Diaminobutyric Acid
DCM Dichloromethane
DIC N,N′-Di(propan-2-yl)methanediimine
DMF N,N-Dimethylformamide
DOTA 2,2′,2″,2‴-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)
tetraacetic acid
DOTA-tris(tBu)-NHS tri-tert-butyl 2,2′,2″-(10-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)
-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
ESI-MS Electrospray ionization mass spectrometry analyses
Et3N Triethylamine
Eβmax Beta emitter with a maximum energy
Fmoc 9-fluorenylmethoxycarbonyl group
hArg Homoarginine
HCl Hydrogen chloride
His Histidine
HOBt 1H-1,2,3-Benzotriazol-1-ol
HS Human Serum
IC50
L
Half maximal inhibitory concentration
Lipophilicity
logP Decimal logarithm of partition coefficient
m/z Mass-to-charge ratio
mAb Monoclonal antibodies
NH2 Amino group
NRP-1 Neuropilin-1
P Partition coefficient
Pbf Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl group
PBS
PhOH
Phosphate-buffered saline
Phenol
PhSiH3 Phenylsilane
RP-HPLC Reverse-Phase High Pressure Liquid Chromatography
RT Retention time
RTKs Receptor Tyrosine Kinases
SD Standard deviation
SH Thiol group
SPPS Solid Phase Peptide Synthesis
t1/2 Half-life time
TFA Trifluoroacetic acid
TIPS Tri(propan-2-yl)silane
VEGF Vascular Endothelial Growth Factor
VEGF-A165 Vascular Endothelial Growth Factor-A165
VEGFR Vascular Endothelial Growth Factor Receptor
VEGFR-2 Vascular Endothelial Growth Factor Receptor 2
sigma; operator for summation