A7R | Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH peptide |
ACN | Acetonitrile |
ADME | Absorption, distribution, metabolism, and excretion |
Ahx | 6-aminohexanoic acid |
Alloc | Allyloxycarbonyl group |
Ao | Organic phase radioactivity |
Aw | Aqueous phase radioactivity |
Boc COOH |
Tert-butyloxycarbonyl group Carboxyl group |
Cys | Cysteine |
Dab | 2,4-Diaminobutyric Acid |
DCM | Dichloromethane |
DIC | N,N′-Di(propan-2-yl)methanediimine |
DMF | N,N-Dimethylformamide |
DOTA | 2,2′,2″,2‴-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl) tetraacetic acid |
DOTA-tris(tBu)-NHS | tri-tert-butyl 2,2′,2″-(10-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethyl) -1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate |
ESI-MS | Electrospray ionization mass spectrometry analyses |
Et3N | Triethylamine |
Eβmax | Beta emitter with a maximum energy |
Fmoc | 9-fluorenylmethoxycarbonyl group |
hArg | Homoarginine |
HCl | Hydrogen chloride |
His | Histidine |
HOBt | 1H-1,2,3-Benzotriazol-1-ol |
HS | Human Serum |
IC50 L |
Half maximal inhibitory concentration Lipophilicity |
logP | Decimal logarithm of partition coefficient |
m/z | Mass-to-charge ratio |
mAb | Monoclonal antibodies |
NH2 | Amino group |
NRP-1 | Neuropilin-1 |
P | Partition coefficient |
Pbf | Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl group |
PBS PhOH |
Phosphate-buffered saline Phenol |
PhSiH3 | Phenylsilane |
RP-HPLC | Reverse-Phase High Pressure Liquid Chromatography |
RT | Retention time |
RTKs | Receptor Tyrosine Kinases |
SD | Standard deviation |
SH | Thiol group |
SPPS | Solid Phase Peptide Synthesis |
t1/2 | Half-life time |
TFA | Trifluoroacetic acid |
TIPS | Tri(propan-2-yl)silane |
VEGF | Vascular Endothelial Growth Factor |
VEGF-A165 | Vascular Endothelial Growth Factor-A165 |
VEGFR | Vascular Endothelial Growth Factor Receptor |
VEGFR-2 | Vascular Endothelial Growth Factor Receptor 2 |
∑ | sigma; operator for summation |