Table 4.
List of DE genes found between CD4+CD8+ DP cells of D+L and D-L cohorts.
| Gene Symbol | Encoded Protein | p-Value | Log2FC | FDR | Gene Product Function * |
|---|---|---|---|---|---|
| Reduced expression in CD4+CD8+ DP cells of D+L cohort | |||||
| DNAJB1 | DnaJ homolog subfamily B member 1 | 1.36E-07 | −2.12 | 7.96E-03 | ATPase activator activity, transcription corepressor activity, Hsp70 protein binding, involved in protein folding |
| NR4A2 | Nuclear receptor subfamily 4 group A member 2 | 1.49E-07 | −3.08 | 8.72E-03 | RNA polymerase II regulatory region sequence-specific DNA binding |
| B3GNT7 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase | 1.31E-07 | −5.48 | 7.66E-03 | Acetylglucosaminyltransferase activity, protein binding |
| SLC45A1 | Proton-associated sugar transporter A | 6.06E-07 | −5.39 | 3.53E-02 | Sucrose:proton symporter activity |
| Higher expression in CD4+CD8+ DP cells of D+L cohort | |||||
| ABO | Histo-blood group ABO system transferase | 3.11E-10 | 4.62 | 1.82E-05 | Glycosyltransferase activity |
Log2FC, log2 fold change; FDR, false-discovery rate; DE genes cut off: FDR < 0.05 and Log2FC > 2, * Gene protein products with functional annotation information was extracted from UniProt Consortium [26].