Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Alternate mechanisms of JAK inhibition. Deucravacitinib inhibits TYK2 activation by interacting with the pseudokinase (JH2) domain (allosteric inhibition), while first-generation jakinibs inhibit enzymatic activity by binding to the ATP-binding (JH1) domain (competitive inhibition).
