Table 3.

Summary of jakinib time to peak concentration and functional half-life.

JAK Inhibitor	Time to Peak Concentration	Half-Life (Hours)	References
ruxolitinib	<2 h	approximately 3 h	[151]
5 most common ruxolitinib metabolites	1.5–2 h	4.3–5.7 h	[150]
tofacitinib	0.5–1 h	3 h	[152]
baricitinib	0.75–1 h	5.9–7.4 h	[153]
upadacitinib	within 1 h 1; 2–3 h 2	4 h	[154,155]
filgotinib	0.5–5 h	5–6 h	[152]
GS829845	3–5 h	20–23 h	[156]

¹ Immediate-release formula. ² Extended-release formula.