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. 2021 Dec 23;58(1):16. doi: 10.3390/medicina58010016

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Chromatin Condensation in Aberrant Microglia and Oligodendrocytes in Diabetic Female db/db Models in Grey Matter—Cortical Layer III. This multipanel collage illustrates chromatin condensation in aberrant activated microglia cell(s) (aMGC) and aberrant oligodendrocytes (OL-OLG). Panels (A,D) illustrate the normal microglia cell (MGC) and oligodendrocyte in control non-diabetic models respectively. Note the abnormal aberrant mitochondria (aMt) in the microglia and neural cells in panels (B,E) respectively with aMt (highlighted yellow circles encircled in red). Panels (C,F) depict chromatin condensation (Chr Cond) within the nuclei of aberrant microglial cells and oligodendrocytes respectively. Also, note arrows in panel E depict myelin splitting and separation and arrowheads depict chromatin condensation in the nuclei (panels (C,F)). aMGCs and aberrant oligodendrocytes suggest abnormal crosstalk with abnormal myelin remodeling and impaired folate one-carbon metabolism. Magnification and scale bar varies. Images in this figure were provided and approved by CC 4.0 [32,33]. M = myelin; N = nucleus; NVU = neurovascular unit; Ol-Olig = oligodendrocyte.