Figure 4.

Formate Plays a Central and Formidable Role in Providing Proper Nucleus Function and Structure. Serine, glycine, methionine and choline are also necessary components to fulfill proper mitochondrial function to the nucleus in order to produce purines, thymidylate and methionine to fulfil their role in the nucleus. This figure depicts the importance of the folate dependent pathway (green coloring) for formate synthesis in the mitochondria and the central role for the formidable formate to be utilized by the nucleus for proper chromatin modeling. Note the bold and underlining of the important carbon unit in the chemical formula for formate. Also, note the folate independent pathway on the right-hand side of this figure. The concept for this slide design was derived from reference [35].