Table 6.

Analytical techniques/assays to detect Tyr oxidation products with the corresponding analytical techniques and relevant references.

Amino Acid Residue	Oxidized Amino Acid Residues	Analytical Technique	Reference
Tyr	Di-Tyr	UV spectroscopy	Hawkins et al. (2009) [280]
		Fluorescence spectroscopy	Malencik et al. (1996) [293]
		Affinity & RP-HPLC with fluorescence detection	Malencik et al. (1996), Davies et al. (2001), Mahmoud et al. (1995), Malencik et al. (2003) [293,294,295,299]
	Di-Tyr, Tyr-Trp, Tyr-Lys, Tyr-His	ESI-MS/MS (and with 18O labeling with trypsin)	Mukherjee et al. (2017), Atwood et al. (2004), Trnka et al. (2014), Mariotti et al. (2018), Degendorfer et al. (2018), Leinisch et al. (2018) [185,220,253,254,255,300,301]
	Di-Tyr	Immunodetection	Kato et al. (1998), Kato et al. (2000) [302,303]
	DOPA	SDS-Page	Paz et al. (1991) [304]
	DOPA, o-Tyr, m-Tyr	Fluorescence spectroscopy	Creed et al. (1984), Kerwin et al. (2007) [3,256]
	DOPA	UV- spectroscopy	Waite et al. (1984) [305]
		HPLC with fluorescence detection	Armstrong et al. (1995) [306]
		HPLC with electrochemical detection	Armstrong et al. (1995), Ke et al. (2016), Kumarathasan et al. (2003) [306,307,308]