Figure 3.

(a) Test channel after blood flow experiments for 48 min: the test channel contains (1) coated fibers with NOrel microgels and (2) control bare fibers. Uncoagulated blood can be seen within the test channel (1), while the blood clots are significantly found on the inner wall of the test channel (2). In the same way, the visual inspection of the extracted fibers from the corresponding test channel right after the blood flow experiment shows (3) no stable clot on the NOrel coated fiber, while (4) the significant layers of clot cover the surface of the uncoated fiber. (b) SEM analysis of the fibers used in the blood flow experiment: (1) the absence of any fibrin network on the surface of the NOrel coated fiber while (2) a dense layer of clot formed on the bare fiber after contacting the blood flow w/o infusion of supplementary S-nitrosoglutathione (GSNO). (3) A clot-free surface of the coated fiber was observed, while (4) low but still significant fibrin layers settled on the control fiber after exposure to the blood flow with supplementary GSNO. The insets indicate the wide field of view, respectively. Scale bar: 500 µm.