Table 4.
The main interactions between the Omicron spike protein and human ACE2 receptor.
| ACE2 | WT Spike | Omicron Spike |
|---|---|---|
| S19 | A475 | A475 (2) |
| Q24 | A475, G476, S477, F486, N487, Y489 | A475, G476, A477, F486, N487, Y489 |
| T27 | F456, Y473, A475, Y489 | F456, Y473, A475, Y489 |
| P28 | N487, Y489 | N487, Y489 |
| D30 | K417, L455, F456 | N417, L455, F456, R493 |
| K31 | L455, F456, GLU484, Y489, F490, Q493 | L455, F456, Y489, F490, R493 |
| F32 | --- | R493 |
| H34 | K417, Y453, L455, Q493 | N417, Y453, L455, R493 |
| E35 | Q493, R403, Y505 | R493, R403, Y501, H505 |
| D38 | Y449, G496, Q498 | Y449, S496, R498, Y501 |
| F40 | --- | Y501 |
| Y41 | Q498, T500, N501 | R498, T500, Y501 |
| Q42 | V445, G446, G447, Y449, Q498 | V445, S446, G447, Y449, R498, Y501 |
| L45 | V445, Q498, T500, F486 | V445, R498, T500, F486 |
| M82 | F486 | F486 |
| Y83 | F486, N487, Y489 | F486, N487, Y489 |
| N330 | T500 | T500, T500 |
| L351 | --- | R498, Y501 |
| G352 | --- | Y501, H505 (2) |
| k353 | Y495, G496, F497, Q498, T500, N501, G502, Y505 | Y4895, S496, F497, R498, T500, Y501 |
| G354 | T500, N501, G502, V503, Y505 | T500, Y501, G502, V503, H505 |
| D355 | T500, N501, G502 | R498, T500, Y501, G502, H505 |
| R357 | T500 | R498, T500 |
| A386 | Y505 | --- |
| R393 | Y505 | --- |
---–No interactions present. (2) Two different interactions with the same residue. The mutated residues present in the RBD that interact with the ACE2 receptor are shown in bold.