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. 2022 Jan 15;11(1):101. doi: 10.3390/pathogens11010101

Figure 3.

Figure 3

Immunohistochemical analysis positive for E-selectin, P-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and very late antigen-4 (VLA-4) in zones Z3, Z2, Z1, and PT in the hepatic parenchyma of yellow fever fatal cases and in yellow fever negative controls. Immunostaining for E-selectin (a), P-selectin (b), ICAM-1 (c), VCAM-1 (d), and VLA-4 (e) in the endothelial cells (black circle) of -Z3, -Z2, -Z1 and inflammatory infiltrate (PT) (black circle). Z3: Centrolobular zone; Z2: Midzonal zone; Z1: Periportal zone; PT: Portal tract; p ≤ 0.0001. In negative controls (NC): Light labelling for E-selectin and preservation of the PT (yellow circle), and absence of labelling and preservation of the PT for P-selectin, ICAM-1, VCAM-1, and VLA-4 (yellow circles). 400×, scale bar (20 µm).