Skip to main content
. 2022 Jan 10;27(2):443. doi: 10.3390/molecules27020443

Figure 2.

Figure 2

MiR-126-5p binds to TDO2 and influences the expression of the related signaling pathway proteins. (A) Atlas of plasmid (psiCHECK-2 Vector) was used for dual luciferase assays. (B) After transfection with miR-NC or miR-126-5p in HEK293T cells, the relative luciferase activity of mutant or wild-type TDO2 3′-UTR was detected. (C) Effect of 126m (miR-126-5p mimics), 126i (miR-126-5p inhibitors), 604 (siRNA-TDO2) on signaling pathways and TDO2 expression. All experiments were conducted at least three independent times, and all the values were presented as mean ± standard error of the mean (SEM). * p < 0.05, ** p < 0.01, *** p < 0.001.