Table 3.
Major toxicokinetic characteristics of OTA after single oral bolus administration, with and without the binder YHY. Values are presented as mean (n = 6) ± SD.
| Toxicokinetic Parameters | OTA | OTA + YHY | p Value |
|---|---|---|---|
| AUC0–96 h (h.µg/mL) | 14.13 ± 1.48 | 12.28 ± 2.06 | 0.135 |
| AUC0–4 h (h.µg/mL) | 1.42 ± 0.24 | 1.14 ± 0.25 | 0.288 |
| Cmax (ng/mL) | 426.23 ± 85.10 | 353.83 ± 64.21 | 0.076 |
| Tmax (h) | 2.42 ± 1.06 | 2.04 ± 0.65 | 0.853 |
| T1/2 el (h) | 45.12 ± 6.61 | 50.69 ± 12.40 | 0.464 |
| ke (1/h) | 0.016 ± 0.002 | 0.015 ± 0.004 | 0.674 |
| Relative F AUC0–96 h (%) | / | 86.86 | |
| Relative F AUC0–4 h (%) | / | 79.86 |
Abbreviations are as in Table 2.