Table 4.
Major toxicokinetic characteristics of ZEA-GlcA after single oral bolus administration, with and without the binder YHY. Values are presented as mean (n = 6) ± SD.
| Toxicokinetic Parameters | ZEA | ZEA + YHY | p Value |
|---|---|---|---|
| AUC0–8 h (h.peak area/mL) | 2168.20 ± 494.87 | 1917.16 ± 444.98 | 0.985 |
| AUC0–0.5 h (h.peak area/mL) | 505.92 ± 227.89 | 407.48 ± 141.70 | 0.765 |
| Cmax (peak area/mL) | 1627.15 ± 737.12 | 1302.53 ± 485.21 | 0.308 |
| Tmax (h) | 0.33 ± 0.14 | 0.29 ± 0.07 | 0.482 |
| T1/2 el (h) | 3.60 ± 2.00 | 2.93 ± 0.85 | 0.523 |
| ke (1/h) | 0.27 ± 0.12 | 0.27 ± 0.05 | 0.533 |
| Relative F AUC0–8 h (%) | / | 88.42 | |
| Relative F AUC0–0.5 h (%) | / | 80.54 |
Abbreviations are as in Table 2.