Figure 3.

Reduced colitis symptoms in Parp7^−/− mice. (A) Parp7^−/− mice present lower intestinal inflammation symptoms than Parp7^+/+ mice as indicated by a reduced disease activity index (DAI) on day 6 of DSS treatment. * p < 0.05 student’s t-test. Parp7^+/+ mice have a greater reduction in colon length (B) and liver weight (C) on day 6 of DSS treatment compared with Parp7^−/− mice. * p < 0.05 two-way ANOVA compared with genotype-matched and DSS treated mice. (D) Parp7^−/− mice exhibit less tissue damage and immune cell infiltration than Parp7^+/+ mice. Representative H&E staining of colon section after 6 days of exposure to 2% DSS in drinking water and after water recovery. The yellow arrows indicate immune cell infiltration.