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. 2022 Jan 15;23(2):920. doi: 10.3390/ijms23020920

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Lower expression of proinflammatory genes is observed in DSS-exposed Parp7^−/− mice. Intestinal mRNA expression levels of (A) Il1β, (B) Il6, (C) Il17, (D) Lcn2, (E) Cxcl1, (F) Cxcl2, (G) Il10, and (H) Il22 in colon tissue isolated from Parp7^+/+ and Parp7^−/− mice that were not exposed to DSS (-DSS) or exposed to 2% DSS in their drinking water for 6 days or 12 days (6 days DSS followed by 6 days water). The relative mRNA levels of the indicated genes were determined with RT-qPCR. * p < 0.05 two-way ANOVA compared with genotyped-matched and DSS treated animals. ^# p < 0.05 two-way ANOVA compared with time matched Parp7^+/+ mice.