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. 2022 Jan 16;15:345–362. doi: 10.2147/JIR.S349186

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© 2022 Xu et al.

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Landscape of genetic and transcriptomic variation of pyroptosis-related regulators in breast cancer. (A) 26 of the 986 BC patients experienced genetic alterations of 10 PRRs, with a frequency of 2.64%, mostly including missense mutation and nonsense mutation. (B) The CNV frequency of 10 PRRs was prevalent. The column represented the alteration frequency. The deletion frequency, green dot; The amplification frequency, pink dot. (C) PCA of 10 PRRs to distinguish BC from normal samples. (D) The difference of mRNA expression levels of 10 PRRs between BC and normal samples. The asterisks represented the statistical P-value (**P < 0.01; ***P < 0.001).